Project

biotechnology netherlands

Targeting RNA Dicing

Modular Therapeutics is addressing one of the biggest challenges in medicine: many patients do not respond to existing treatments because their disease is driven by unique molecular changes that current drugs cannot target, often due to an insufficient understanding of the biological impact of these mutations. Our innovation is based on a newly discovered biological process called RNA dicing – a natural way in which cells cut and rewire genetic messages. We have found that this process can produce protein variants that play a key role in cancer, immune disorders, and other diseases.

Our technology combines advanced genetic analysis with machine learning models to detect these disease-causing variants in patient samples. This enables us to match patients with the most effective existing medicines or to guide the development of entirely new treatments. The modular nature of our approach means it can be quickly adapted to different diseases, potentially benefiting millions of patients worldwide.

Within the Biotech Booster program, we will refine our detection technology, focusing on abundant oncogenic mutations in endometrial cancer, validate it using patient samples, and lay the groundwork for personalized therapies. Our ultimate goal is to accelerate the path from discovery to treatment, improving patient outcomes and reducing healthcare costs.

Project team

Frédéric Amant (Project Leader, NKI-AVL), Yuval Malka (Co-lead Modular, Therapeutics), Willem-Jan Keune (Business Developer, NKI-AVL & Biotech Booster)

Project Number

BIOB25006

Year granted

2025

Status

Ongoing

Applicant

Netherlands Cancer Institute

Funding

€ 199.745

Sector/Industry

Health & Pharma

SDG's

Good health and well-being (SDG 3)

Thematic Cluster

TC5: Vaccines, Small Molecules, Discovery & Development Platforms

Level

Level 1
Molecuul

2025

Year granted

Netherlands Cancer Institute

Applicant

€ 199.745

Project funded
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Biotechnology netherlands

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Biotechnology netherlands

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