lab-on-a-particle CRISPR detection
Accurate and early detection of diseases is key to improving healthcare, but current diagnostic tests often lack precision, leading to delays, false alarms, and higher healthcare costs. Our innovative solution uses advanced nanotechnology and CRISPR—a cutting-edge molecular tool—to create ultra-sensitive tests that detect tiny traces of disease markers at very early stages. These tests are […]
Glow-in-the-dark molecular diagnostics
Quantitative PCR (qPCR) is a versatile and sensitive diagnostic method that is the golden standard for DNA and RNA detection. However, qPCR requires expensive equipment, expert technicians and dedicated laboratory facilities, all leading to test times of multiple hours. The COVID-19 pandemic highlighted both the strength of qPCR for infectious disease detection (ease of development, […]
Next generation formulations for RNA
Liporyx is developing a bioinspired lipid-like polymer technology to safely and specifically deliver nucleic acid therapeutics to diverse cell types in the body. Most RNA therapeutics do not traverse the body well and are typically removed from circulation by the liver, limiting their effectiveness for many diseases. A highly versatile drug delivery system lies at […]
Macrophage Liposomes
Despite many advancements in cancer treatment, more than 10 million people die each year from cancer worldwide. The most advanced cancer immunotherapy benefits only 10-15% of the treated patients with solid tumors and metastasis. This low response rate is due to suppressed tumor cell-killing immune cells. This suppression is caused by tumour-associated macrophages (TAM), key […]
EV antibodies for the treatment of cancer
Tumour cells communicate with normal cells in the body through special communication bubbles called vesicles. After they reach a healthy cell, this cell is reprogrammed to the benefit of the cancer cell. Until now, no strategies to block these vesicles released by cancer cells have been developed due to lack specific markers and molecules. Recently […]
Fenix Therapeutics
Fenix Therapeutics aims to reshape cancer outcomes, providing hope to patients by transforming the future of oncology through more specific and effective treatments. Our interdisciplinary team of accomplished cancer biologists, oncologists, and chemists ensures the innovative success of our approach. Together, we can transform the landscape of cancer treatment and positively impact the lives of many cancer patients and their […]
On-site Readout of CHips for Infectious Disease Diagnostics (ORCHIDD)
Infectious diseases are a major global challenge. The COVID-19 pandemic demonstrated how even mild pathogens can disrupt society, while antimicrobial resistance continues to rise at an alarming rate. Sepsis, a life-threatening response to infection, is responsible for 1 in 5 deaths worldwide, and this number is growing. These challenges underscore the urgent need for faster […]
T-Guard
Philikos is developing T-Guard, an innovative treatment for systemic sclerosis, a severe autoimmune disease where the immune system attacks the body’s own cells and organs. This leads to scar tissue formation that impairs function and, in severe cases, can be fatal. Diffuse cutaneous Systemic Sclerosis (dcSSc) is the most aggressive form, with nearly half of […]
BiloMedics
Cholestatic liver diseases (CLDs), result in severe impairment of liver function and ultimately in liver failure. Patients with these diseases suffer from severe persistent itch and failure to thrive (in young children), and may develop hepatocellular carcinoma. Due to the lack of long-term effective pharmacological treatment options, liver transplantation is often necessary for survival. Unfortunately, […]
Malaria Vaccine
Every year, more than half a million people die from malaria, mainly children under five in sub-Saharan Africa. Malaria is caused by parasites that are transmitted through mosquitoes. Recently, two vaccines have become available that protect children from infection when they are bitten by infected mosquitoes. Although these vaccines will save the lives of many, […]
