Antimicrobial Nanoparticles
The problem: Antibiotic resistance is a growing global health threat, causing 1.3 million deaths annually, but no new classes of antibiotics have been developed since 1984. Bacteria combat antibiotics by forming protective biofilms, reducing uptake of antibiotics, enzymatically degrading antibiotics, or actively pumping them out through efflux pumps. Without a new strategy for antibiotics delivery, […]
Next generation formulations for RNA
Liporyx is developing a bioinspired lipid-like polymer technology to safely and specifically deliver nucleic acid therapeutics to diverse cell types in the body. Most RNA therapeutics do not traverse the body well and are typically removed from circulation by the liver, limiting their effectiveness for many diseases. A highly versatile drug delivery system lies at […]
Gelion Care
Diabetic foot ulcers (DFUs) are a common and severe complication of diabetes that affects millions worldwide. DFUs are slow to heal, prone to infections, and often lead to amputations, creating a significant healthcare burden. Existing treatments are costly, inaccessible, or ineffective, and the rising threat of Anti-Microbial Resistance (AMR) further limiting traditional options. At Gelion […]
Macrophage Liposomes
Despite many advancements in cancer treatment, more than 10 million people die each year from cancer worldwide. The most advanced cancer immunotherapy benefits only 10-15% of the treated patients with solid tumors and metastasis. This low response rate is due to suppressed tumor cell-killing immune cells. This suppression is caused by tumour-associated macrophages (TAM), key […]
EV antibodies for the treatment of cancer
Tumour cells communicate with normal cells in the body through special communication bubbles called vesicles. After they reach a healthy cell, this cell is reprogrammed to the benefit of the cancer cell. Until now, no strategies to block these vesicles released by cancer cells have been developed due to lack specific markers and molecules. Recently […]
T-Guard
Philikos is developing T-Guard, an innovative treatment for systemic sclerosis, a severe autoimmune disease where the immune system attacks the body’s own cells and organs. This leads to scar tissue formation that impairs function and, in severe cases, can be fatal. Diffuse cutaneous Systemic Sclerosis (dcSSc) is the most aggressive form, with nearly half of […]
BiloMedics
Cholestatic liver diseases (CLDs), result in severe impairment of liver function and ultimately in liver failure. Patients with these diseases suffer from severe persistent itch and failure to thrive (in young children), and may develop hepatocellular carcinoma. Due to the lack of long-term effective pharmacological treatment options, liver transplantation is often necessary for survival. Unfortunately, […]
Supravision
Age-related macular degeneration (AMD) is the foremost cause of vision impairment in the industrialized world, and no effective treatments are available. The number of patients is expected to increase globally, from around 200 million in 2020 to nearly 300 million in 2040. The condition tremendously impacts reading, face recognition, and driving, causing a loss of […]
OsteoGlycin
Chronic obstructive pulmonary disease (COPD) is a prevalent and deadly lung disease (third leading cause of death worldwide), caused mainly by tobacco smoke and air pollutants. With approximately 300 million patients worldwide, the economic burden is projected to reach INT$ 4.326 trillion by 2050. The key problem underlying COPD pathogenesis is increased tissue destruction and […]
Ninetac
Colorectal cancer (CRC) is a common and often deadly disease. Every year 1.9 Mio. cases and over 900 000 deaths are registered globally. While surgery remains the primary treatment option, radiotherapy and chemotherapy are frequently necessary but come with significant drawbacks. These systemic treatments are toxic to all cells alike, leading to severe side effects […]
