FavaFerment

The EU aims to achieve climate neutrality by 2050, with zero net greenhouse gas emissions. This transition poses significant challenges for the food industry, particularly in reducing the carbon footprint of food products. The protein transition, focussing on plant-based dairy and meat alternatives, is central to this effort. However, consumer acceptance of these alternatives remains […]

FerMetaFix

Fermenting a Healthier Future Microbiome-Inspired Foods for Metabolic Health Obesity and related conditions like diabetes and heart disease are increasing rapidly worldwide, placing a heavy burden on people’s health and healthcare systems. Current medicines can help but they are often costly, have side effects, and remain out of reach for many. At FermBiosis we started […]

Haplotagging

Food security and climate change are two of the greatest challenges facing humanity. With shrinking farmland and a growing population, we need Smart Breeding technologies: technologies that accelerate the creation of crop varieties that increase yield, resist disease, and tolerate heat and drought. Today, many bottlenecks exist to make Smart Breeding affordable only to the […]

Athero-Screen

Despite effective lipid-lowering therapies, patients remain at risk of cardiovascular disease. By 2030, cardiovascular disease (CVD) is expected to affect about 41% of the Western population. This increase will significantly raise healthcare costs, with U.S. expenditures on CVD projected to triple between 2010 and 2030. Many CVD drugs fail in clinical trials due to a […]

ENRICH-SARCOMA

Sarcomas are soft tissue tumors with limited treatment options, which often include radiation therapy. For some sarcomas, the benefit of radiation is limited, and enhancing its effect could improve patient outcomes. Our research has focused on radiosensitization: increasing the sensitivity of tumors to radiation. We do this via administration of drugs that enrich tumor cells […]

sideroFORCE

Each year, around 7.7 million deaths are linked to bacterial infections, with 4.95 million caused by drug-resistant pathogens. Indeed, antimicrobial resistance undermines the benefits of effective antibiotics, becoming a significant barrier towards achieving the Sustainable Development Goals related to health and poverty alleviation. Although it is of eminent importance to reduce the misuse and overuse […]

tRNA for CMT

Charcot-Marie-Tooth (CMT) disease is a common inherited condition that causes progressive muscle weakness, loss of sensation, and disability. CMT disease type 2D, one of the most severe forms of the disease, is caused by mutations that result in dysfunctional glycyl-tRNA synthetase. Millions of CMT patients worldwide currently face limited treatment options that only manage symptoms […]

Dual Tumor Targeting

Immunotherapy using antibodies targeting tumors has led to important clinical advances, yet only 15-20% of all cancer patients respond to immunotherapy. Thus, there is urgent need to increase the efficacy for immunotherapies and enhance anti-tumor responses. This is exemplified by hematological malignancies including diffuse large B-cell lymphoma (DLBCL) and multiple myeloma (MM), two common and […]

MycoSafe

Globally, 20% of all food and feed — including beverages — is lost to fungal spoilage, while multi-drug resistance in fungal pathogens continues to rise. Current preservation measures rely on energy-intensive processes like pasteurization, or chemical additives such as sulfites and benzoates which are known allergens. Increasing demand for clean-label products and the EU’s push […]

Tulip Enzyme Solutions

Many chemical and pharma processes in the industry rely on inefficient or environmentally harmful methods. Biocatalysis offers a greener alternative, but natural enzymes and cofactors are expensive both to develop as well as to use in the processes. However, widespread adoption of biocatalysis is still limited by challenges related to toxicity, impurities and cost. To […]