On-site Readout of CHips for Infectious Disease Diagnostics (ORCHIDD)
Infectious diseases are a major global challenge. The COVID-19 pandemic demonstrated how even mild pathogens can disrupt society, while antimicrobial resistance continues to rise at an alarming rate. Sepsis, a life-threatening response to infection, is responsible for 1 in 5 deaths worldwide, and this number is growing. These challenges underscore the urgent need for faster […]
T-Guard
Philikos is developing T-Guard, an innovative treatment for systemic sclerosis, a severe autoimmune disease where the immune system attacks the body’s own cells and organs. This leads to scar tissue formation that impairs function and, in severe cases, can be fatal. Diffuse cutaneous Systemic Sclerosis (dcSSc) is the most aggressive form, with nearly half of […]
BiloMedics
Cholestatic liver diseases (CLDs), result in severe impairment of liver function and ultimately in liver failure. Patients with these diseases suffer from severe persistent itch and failure to thrive (in young children), and may develop hepatocellular carcinoma. Due to the lack of long-term effective pharmacological treatment options, liver transplantation is often necessary for survival. Unfortunately, […]
SupraVision
Age-related macular degeneration (AMD) is the foremost cause of vision impairment in the industrialized world, and no effective treatments are available. The number of patients is expected to increase globally, from around 200 million in 2020 to nearly 300 million in 2040. The condition tremendously impacts reading, face recognition, and driving, causing a loss of […]
Malaria Vaccine
Every year, more than half a million people die from malaria, mainly children under five in sub-Saharan Africa. Malaria is caused by parasites that are transmitted through mosquitoes. Recently, two vaccines have become available that protect children from infection when they are bitten by infected mosquitoes. Although these vaccines will save the lives of many, […]
Super Mendelian Microfactories
Yeast has been used for centuries to make bread, beer, and wine. Since the late 20th century, it has also been used to produce important medicines like insulin. For the bioeconomy, where biological processes create sustainable products, yeast can be harnessed to make a wide range of products, from flavours and fragrances to materials and […]
Evoducta
Many everyday products are produced through fermentation by microorganisms—some obvious, like the yoghurt you have for breakfast; others less obvious, like the citric acid in your favourite soda. The long list of industrial fermentation processes continues to grow for two key reasons: (1) They can produce complex substances that are otherwise difficult or impossible to […]
Constellate
CONSTELLATE helps protein-based therapeutics developers roll out life-saving drugs faster by accelerating critical analyses in drug development. To produce a protein-based therapeutic, developers employ living cells. These cells often modify the therapeutic by, for instance, attaching large sugar molecules to it. It is critical to monitor such modifications as they influence the activity and stability […]
iProtics
iProtics is developing a novel drug to treat blood cancers and autoimmune diseases more effectively and with fewer side effects than current treatments. Existing drugs inhibit both immunoproteasomes and constitutive proteasomes, causing severe side effects by damaging healthy cells. iProtics has created a first-in-class drug that selectively inhibits only immunoproteasomes, which are primarily found in […]
Hello R&D
We are HelloR&D, a liver toxicity prediction company for novel drugs, compounds and chemicals. Based on our proprietary technology, the hepatocyte-like liver organoids (HeLLOs), we are developing a comprehensive toxicity testing platform to provide mechanistic insights for drug developers. With this, we help derisking and instructing further development. We have already validated our technology to […]