Glow-in-the-dark molecular diagnostics
Quantitative PCR (qPCR) is a reliable and sensitive method for detecting DNA and RNA, and is widely considered the gold standard. However, qPCR needs costly equipment, skilled technicians, and specialized labs, which means tests can take several hours. The COVID-19 pandemic showed that while qPCR is effective for detecting infectious diseases, it is neither quick […]
Next generation formulations for RNA
Liporyx is developing a bioinspired lipid-like polymer technology to safely and specifically deliver nucleic acid therapeutics to diverse cell types in the body. Most RNA therapeutics do not traverse the body well and are typically removed from circulation by the liver, limiting their effectiveness for many diseases. A highly versatile drug delivery system lies at […]
Gelion Care
Diabetic foot ulcers (DFUs) are a common and severe complication of diabetes that affects millions worldwide. DFUs are slow to heal, prone to infections, and often lead to amputations, creating a significant healthcare burden. Existing treatments are costly, inaccessible, or ineffective, and the rising threat of Anti-Microbial Resistance (AMR) further limiting traditional options. At Gelion […]
Macrophage Liposomes
Despite many advancements in cancer treatment, more than 10 million people die each year from cancer worldwide. The most advanced cancer immunotherapy benefits only 10-15% of the treated patients with solid tumors and metastasis. This low response rate is due to suppressed tumor cell-killing immune cells. This suppression is caused by tumour-associated macrophages (TAM), key […]
EV antibodies for the treatment of cancer
Tumour cells communicate with normal cells in the body through special communication bubbles called vesicles. After they reach a healthy cell, this cell is reprogrammed to the benefit of the cancer cell. Until now, no strategies to block these vesicles released by cancer cells have been developed due to lack specific markers and molecules. Recently […]
Fenix Therapeutics
Fenix Therapeutics aims to reshape cancer outcomes, providing hope to patients by transforming the future of oncology through more specific and effective treatments. Our interdisciplinary team of accomplished cancer biologists, oncologists, and chemists ensures the innovative success of our approach. Together, we can transform the landscape of cancer treatment and positively impact the lives of many cancer patients and their […]
On-site Readout of CHips for Infectious Disease Diagnostics (ORCHIDD)
Infectious diseases are a major global challenge. The COVID-19 pandemic demonstrated how even mild pathogens can disrupt society, while antimicrobial resistance continues to rise at an alarming rate. Sepsis, a life-threatening response to infection, is responsible for 1 in 5 deaths worldwide, and this number is growing. These challenges underscore the urgent need for faster […]
T-Guard
Philikos is developing T-Guard, an innovative treatment for systemic sclerosis, a severe autoimmune disease where the immune system attacks the body’s own cells and organs. This leads to scar tissue formation that impairs function and, in severe cases, can be fatal. Diffuse cutaneous Systemic Sclerosis (dcSSc) is the most aggressive form, with nearly half of […]
BiloMedics
Cholestatic liver diseases (CLDs), result in severe impairment of liver function and ultimately in liver failure. Patients with these diseases suffer from severe persistent itch and failure to thrive (in young children), and may develop hepatocellular carcinoma. Due to the lack of long-term effective pharmacological treatment options, liver transplantation is often necessary for survival. Unfortunately, […]
SupraVision
Age-related macular degeneration (AMD) is the foremost cause of vision impairment in the industrialized world, and no effective treatments are available. The number of patients is expected to increase globally, from around 200 million in 2020 to nearly 300 million in 2040. The condition tremendously impacts reading, face recognition, and driving, causing a loss of […]