NanoLoom

Molecules (proteins) that bind to DNA in our cells play a crucial role in viral and microbial infections, rare diseases, and cancer: developing drugs that interfere with the function of these proteins would allow us tackle many medical challenges. Single-molecule approaches have greatly advanced our understanding of DNA processes in academic research, but traditional single-molecule […]

Fenix Therapeutics

Although traditional Notch/γ-secretase inhibitors (GSI) hold great promise for the treatment of cancer and associated therapy resistance, their clinical approval has been hampered by serious side effects. Our breakthrough technology allowed for the development of FTX-312 and FTX-361, first-in-class prodrugs that release Notch inhibitors exclusively in tumors through an hypoxia dependent mechanism (HyGSI), -a tumor […]

Malaria Vaccine

Every year, more than half a million people die from malaria, mainly children under five in sub-Saharan Africa. Malaria is caused by parasites that are transmitted through mosquitoes. Recently, two vaccines have become available that protect children from infection when they are bitten by infected mosquitoes. Although these vaccines will save the lives of many, […]

Constellate

CONSTELLATE helps protein-based therapeutics developers to roll out life-saving drugs faster by accelerating critical analyses in drug development. To produce a protein-based therapeutic, developers employ living cells. These cells often modify the therapeutic by, for instance, attaching large sugar molecules to it. It is critical to monitor such modifications as they influence the activity and […]

Iprotics

iProtics is developing a novel drug to treat blood cancers and autoimmune diseases more effectively and with fewer side effects than current treatments. Existing drugs inhibit both immunoproteasomes and constitutive proteasomes, causing severe side effects by damaging healthy cells. iProtics has created a first-in-class drug that selectively inhibits only immunoproteasomes, which are primarily found in […]

Hello R&D

We are HelloR&D, a liver toxicity prediction company for novel drugs, compounds and chemicals. Based on our proprietary technology, the hepatocyte-like liver organoids (HeLLOs), we are developing a comprehensive toxicity testing platform to provide mechanistic insights for drug developers. With this, we help derisking and instructing further development. We have already validated our technology to […]

Silver Bullet

At Leiden University, and our spin-off company GenLumina, we are working on innovative ways to treat cancer. We develop tiny, DNA-based structures that can target and treat cancer cells with incredible precision. Imagine an automated treatment device that detects cancer on or in the body, and delivers light to effectively treat it with minimal side […]

PanaxTX

Corticosteroid drugs, such as dexamethasone and prednisolone, are among the most prescribed drugs in the world. These immune-suppressive drugs are very effective against inflammatory and auto-immune diseases, such as asthma, psoriasis, inflammatory bowel disease and rheumatoid arthritis. However, their use is limited by their side effects, which are severe and include osteoporosis, elevated blood sugar […]

Nutritional Bio-Nanoparticles

Surgical repair of critically sized bone defects occurs 2 million times per year. Those defects are typically filled with autologous bone implants. However, due to the inability to maintain the viability of such large bone implants, their essential functionality for tissue healing and regeneration is largely lost, leading to failure of the bone healing process. […]